Hydrodynamics and Stem Cells

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Testing of a special device that is able to pull adult stem cells out of a living rat have provided greater purity than techniques used to date. The device, designed by an associate professor of biomedical engineering at the University of Rochester will be reported in the coming weeks in an issue of the British Journal of Hematology. Says Michael King, associate professor at the University of Rochester, "We're finding we can play off the hydrodynamics of moving blood to isolate and manipulate specific cell population with great efficiency."
Manipulating stem cells, cancer cells, and white blood cells through the mechanics of cell movement has been the focus of King's research in the field. In 2004, he realized that he could coat materials with adhesive selections and capture living adult stem cells. His results were published last month in issues of Biotechnology Progress and Clinical Chemistry.

Says King, "Centrifugal methods produce higher stem cell yields, because they start off with more blood materials." However, he believes his tiny device may be scaled up to allow significantly larger capacity volumes. He hopes that someday, his implantable device will be able to reprogram neutrophils. "One of our ultimate goals", he says, "Is to develop an implantable device that will selectively remove the test excels from the blood. Those cells can breed predate detectable tumors by years so we might catch them before they become dangerous."

Kings research is funded by the New York State foundation for science, technology, and innovation, in addition to CellTraffix.

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